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More than 25 selenoproteins exist, such as phospholipid hydroperoxide GPX[58] and sperm capsular selenoprotein GPX,[59] which help maintain the sperm structural integrity.[60] Morphologic sperm midpiece abnormalities and impairment of sperm motility are among the most common sperm abnormalities associated with Se deficiency.[61] Se has mainly been studied in combination with other vitamins, specifically Vitamin E as it is well known to work in synergy with Se as an antiperoxidant.[62] As previously noted in the randomized controlled trial by Keskes-Ammar et al ., the combination of Vitamin E and Se had protective effects on sperm motility and measures of LPO.[18] Safarinejad et al .[28] reported a statistically significant improvement in all semen parameters in men receiving 200ug of Se alone or in combination with NAC for 26 weeks.[28] In a recent literature review, Se was found to have a favorable influence on viability of spermatozoa providing protection against ROS.[63] Zinc Zinc is an essential mineral involved in the metabolism of DNA and RNA